Fibronectin fragments modulate monocyte VLA-5 expression and monocyte migration
نویسندگان
چکیده
منابع مشابه
Fibronectin fragments modulate monocyte VLA-5 expression and monocyte migration.
To identify the mechanisms that cause monocyte localization in infarcted myocardium, we studied the impact of ischemia-reperfusion injury on the surface expression and function of the monocyte fibronectin (FN) receptor VLA-5 (alpha(5)beta(1) integrin, CD49e/CD29). Myocardial infarction was associated with the release of FN fragments into cardiac extracellular fluids. Incubating monocytes with p...
متن کاملFibronectin fragments containing the RGDS cell-binding domain mediate monocyte migration into the rabbit lung. A potential mechanism for C5 fragment-induced monocyte lung accumulation.
Many inflammatory processes are characterized by an early phase of neutrophil migration and a later phase of monocyte migration into the inflammatory site. Mechanisms that govern the transition between phases are the subject of these investigations. Acute lung inflammation induced by C5 fragments in the rabbit leads to an initial neutrophil influx and plasma leakage into the alveolar space, fol...
متن کاملMonocyte isolation using serum dextrose 5% with autologous plasma
Introduction: Mammalian cells culture is an important method for producing recombinant proteins, monoclonal antibody, and hormones application. One of the common methods in the monocyte isolation is using flask adherent cell culture in RPMI-1640 medium. We aimed, in this study, cell culture medium using dextrose 5% with autologous plasma to produce inexpensive medium for isolation of monocytes....
متن کاملThe amino-terminal 29- and 72-Kd fragments of fibronectin mediate selective monocyte recruitment.
Proteolytic fragments of fibronectin (Fn) can possess properties not inherent to intact Fn. Previously, only mixtures of low molecular weight Fn fragments, and the 120-Kd fibroblastic cell-binding segment, but not intact Fn, were shown to be selectively chemotactic for human monocytes (MOs). In order to determine if other structural domains of Fn were responsible, we tested six Fn fragments. Th...
متن کاملNative and fragmented fibronectin oppositely modulate monocyte secretion of MMP-9.
Monocytes remodel the extracellular matrix (ECM) by secreting proteins composing the ECM such as fibronectin (FN) and degrading proteases such as matrix metalloproteinase-9 (MMP-9), which cleaves FN into fragments. The effects of FN and its fragmented products on the expression of monocyte MMP-9 are controversial and largely unknown. We showed that in human monocytes, the proinflammatory cytoki...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1999
ISSN: 0021-9738
DOI: 10.1172/jci4824